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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 62979Generated: October 29, 2026

3-Chloromethyl-2-isopropylsulfanyl-pyridine → 2-[4-(2-Isopropylsulfanyl-pyridin-3-ylmethoxy)-2,3-dimethyl-phenyl]-cyclopropane carboxylic acid

https://huagongshe.com/reaction/62979

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-Chloromethyl-2-isopropylsulfanyl-pyridineHCID 53816681—
Reactant2-(4-Hydroxy-2,3-dimethyl-phenyl)-cyclopropanecarboxylic acid ethyl esterHCID 90118005—
Product2-[4-(2-Isopropylsulfanyl-pyridin-3-ylmethoxy)-2,3-dimethyl-phenyl]-cyclopropane carboxylic acidHCID 7422297681.3%

Reaction Steps

3-Chloromethyl-2-isopropylsulfanyl-pyridine (0.030 g, 0.149 mmol) obtained in Step C of Preparation Example 1 and 2-(4-hydroxy-2,3-dimethyl-phenyl)-cyclopropane carboxylic acid ethyl ester (0.035 g, 0.149 mmol) obtained in Step C of Preparation Example 48 were used to react sequentially in the same manner as in Steps A and B of Example 1 to obtain the title compound (0.045 g, 81%).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09447044B2
Source datasetuspto-grants-2016_09
ORD IDord-20e48a7476e942228d061ac60c25767f
Source noteuspto-grants-2016_09