HCID 86726370, compound → HCID 86726403, compound

HRID 629791Notes

Reaction equation

[N:1]([C@@H:4]([C@@H:8]([C:16]1[CH:21]=[CH:20][C:19]([Cl:22])=[C:18]([F:23])[CH:17]=1)[C:9]1[CH:10]=[N:11][CH:12]=[C:13]([F:15])[CH:14]=1)[C:5]([OH:7])=O)=[N+]=[N-].[NH2:24][C:25]1[CH:55]=[CH:54][CH:53]=[C:52]([F:56])[C:26]=1[CH2:27][CH2:28][C@H:29]1[O:34][CH2:33][C@@H:32]([CH2:35][O:36][C:37](=[O:44])[NH:38][CH2:39][C:40]([F:43])([F:42])[F:41])[N:31](C(OC(C)(C)C)=O)[CH2:30]1>>[Cl:22][C:19]1[CH:20]=[CH:21][C:16]([C@@H:8]([C:9]2[CH:10]=[N:11][CH:12]=[C:13]([F:15])[CH:14]=2)[C@@H:4]([C:5]([NH:24][C:25]2[CH:55]=[CH:54][CH:53]=[C:52]([F:56])[C:26]=2[CH2:27][CH2:28][C@H:29]2[O:34][CH2:33][C@@H:32]([CH2:35][O:36][C:37](=[O:44])[NH:38][CH2:39][C:40]([F:41])([F:43])[F:42])[NH:31][CH2:30]2)=[O:7])[NH:1][C:37]([O:36][CH3:35])=[O:44])=[CH:17][C:18]=1[F:23]

Participants

Reactant 2

HCID 86726370HCID 86726370, compound

HCID 86726404HCID 86726404, compound

Product 1

HCID 86726403HCID 86726403, compound

Procedure

The title compound was prepared from the product of step 1 and the product of step 4 of Example 99 using the procedures given in steps 2 and 3 of Example 93 and steps 1 and 2 of Example 91. MS (ES) m/z=732 (M+H)+.

Sources & evidence

ORD record: ord-d6a092b97b9b46e2b4d980a512423d97
Source dataset: uspto-grants-2016_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09315475B2

Reaction notes

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