HCID 86726370, compound → HCID 86578368, compound

HRID 629793Notes

Reaction equation

[N:1]([C@@H:4]([C@@H:8]([C:16]1[CH:21]=[CH:20][C:19]([Cl:22])=[CH:18][CH:17]=1)[C:9]1[CH:14]=[CH:13][N:12]=[CH:11][C:10]=1[F:15])[C:5]([OH:7])=O)=[N+]=[N-].[NH2:23][C:24]1[CH:54]=[CH:53][CH:52]=[C:51]([F:55])[C:25]=1[CH2:26][CH2:27][C@H:28]1[O:33][CH2:32][C@@H:31]([CH2:34][O:35][C:36](=[O:43])[NH:37][CH2:38][C:39]([F:42])([F:41])[F:40])[N:30](C(OC(C)(C)C)=O)[CH2:29]1>>[Cl:22][C:19]1[CH:20]=[CH:21][C:16]([C@@H:8]([C:9]2[CH:14]=[CH:13][N:12]=[CH:11][C:10]=2[F:15])[C@@H:4]([C:5]([NH:23][C:24]2[CH:54]=[CH:53][CH:52]=[C:51]([F:55])[C:25]=2[CH2:26][CH2:27][C@H:28]2[O:33][CH2:32][C@@H:31]([CH2:34][O:35][C:36](=[O:43])[NH:37][CH2:38][C:39]([F:42])([F:41])[F:40])[NH:30][CH2:29]2)=[O:7])[NH2:1])=[CH:17][CH:18]=1

Participants

Reactant 2

HCID 86726370HCID 86726370, compound

HCID 86726406HCID 86726406, compound

Product 1

HCID 86578368HCID 86578368, compound

Procedure

The title compound was prepared from (2S,3S)-2-azido-3-(4-chlorophenyl)-3-(3-fluoropyridin-4-yl)propanoic acid (Example 1040, step 1) and the product from step 4 of Example 99 using the procedures given in steps 2-4 of Example 93. MS (ES) m/z=656 (M+H)+.

Sources & evidence

ORD record: ord-d8458fb09c004e22a60759c58e2db8d8
Source dataset: uspto-grants-2016_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09315475B2

Reaction notes

Loading…