HCID 86726370, compound → HCID 86578371, compound

HRID 629796Notes

Reaction equation

HRID 629796 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C@@H:8]([C:13]2[CH:14]=[N:15][CH:16]=[C:17]([C:19]([F:22])([F:21])[F:20])[CH:18]=2)[CH2:9][C:10](O)=[O:11])=[CH:4][CH:3]=1.[NH2:23][C:24]1[CH:54]=[CH:53][CH:52]=[C:51]([F:55])[C:25]=1[CH2:26][CH2:27][C@H:28]1[O:33][CH2:32][C@@H:31]([CH2:34][O:35][C:36](=[O:43])[NH:37][CH2:38][C:39]([F:42])([F:41])[F:40])[N:30](C(OC(C)(C)C)=O)[CH2:29]1>>[F:42][C:39]([F:40])([F:41])[CH2:38][NH:37][C:36](=[O:43])[O:35][CH2:34][C@@H:31]1[CH2:32][O:33][C@H:28]([CH2:27][CH2:26][C:25]2[C:24]([NH:23][C:10](=[O:11])[CH2:9][C@@H:8]([C:5]3[CH:4]=[CH:3][C:2]([F:1])=[CH:7][CH:6]=3)[C:13]3[CH:14]=[N:15][CH:16]=[C:17]([C:19]([F:22])([F:20])[F:21])[CH:18]=3)=[CH:54][CH:53]=[CH:52][C:51]=2[F:55])[CH2:29][NH:30]1

Participants

3

Reactant 2

HCID 86726370HCID 86726370, compoundHCID 86726410HCID 86726410, compound

Product 1

HCID 86578371HCID 86578371, compound

Procedure

The title compound was prepared from the product of step 1 and the product of step 4 of Example 99 using the procedures given in steps 8 and 9 of Example 89. MS (ES) m/z=675 (M+H)+.

Sources & evidence

ORD record
ord-5c386b89a95742e4b1c47bc934dd6a32
Source dataset
uspto-grants-2016_04
Patent number
US09315475B2

Reaction notes

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