1309377-79-4 → HCID 74767793, compound

HRID 629802Notes

Reaction equation

HRID 629802 reaction equation
[N:1]1([CH2:5][CH2:6][N:7]2[CH:11]=[C:10]([C:12]3[CH:17]=[CH:16][N:15]=[C:14]([C:18]([F:21])([F:20])[F:19])[CH:13]=3)[N:9]=[C:8]2[CH:22]2[CH2:27][CH2:26][NH:25][CH2:24][CH2:23]2)[CH2:4][CH2:3][CH2:2]1.Cl[C:29]1[C:34]2[O:35][CH2:36][CH2:37][NH:38][C:33]=2[N:32]=[CH:31][N:30]=1>>[N:1]1([CH2:5][CH2:6][N:7]2[CH:11]=[C:10]([C:12]3[CH:17]=[CH:16][N:15]=[C:14]([C:18]([F:21])([F:19])[F:20])[CH:13]=3)[N:9]=[C:8]2[CH:22]2[CH2:23][CH2:24][N:25]([C:29]3[C:34]4[O:35][CH2:36][CH2:37][NH:38][C:33]=4[N:32]=[CH:31][N:30]=3)[CH2:26][CH2:27]2)[CH2:2][CH2:3][CH2:4]1

Participants

3

Reactant 2

HCID 717571681309377-79-4HCID 894426574-(1-(2-(azetidin-1-yl)ethyl)-2-(piperidin-4-yl)-1H-imidazol-4-yl)-2-(trifluoromethyl)pyridine

Product 1

HCID 74767793HCID 74767793, compound

Procedure

The title compound was prepared according to the procedure described for the preparation of A1 by using 4-(1-(2-(azetidin-1-yl)ethyl)-2-(piperidin-4-yl)-1H-imidazol-4-yl)-2-(trifluoromethyl)pyridine coupled with 4-chloro-7,8-dihydro-6H-pyrimido[5,4-b][1,4]oxazine; LC-MS (M+H=515, obsd.=515);

Sources & evidence

ORD record
ord-c4fe6147b6984974a7201406cbcaaa58
Source dataset
uspto-grants-2016_04
Patent number
US09315517B2

Reaction notes

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