Trifluoroacetic acid → HCID 74767794, compound

Participants

Reaction Conditions

Reaction Steps

To [2-(4-(4-fluoro-3-trifluoromethyl-phenyl)-2-{1-[7-(4-methoxy-benzyl)-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl]-piperidin-4-yl}-imidazol-1-yl)-ethyl]-dimethyl-amine trifluoroacetate (50.0 mg; 0.07 mmol; 1.0 eq.) in a seal tube was added trifluoroacetic acid (1.0 ml). The reaction mixture was stirred at 80° C. for 14 hours. LC-MS showed clean reaction with 99% purity by HPLC. After Removal of TFA, the residue was dissolved in small amount of acetonitrile, added water and then lyophilized to afford the title compound as off-white solid (35 mg, 70% yield); LC-MS (M+H=504, obsd.=504);

Provenance & Evidence