4-Chloro-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidine → HCID 74766821, compound

HRID 629804Notes

Reaction equation

HRID 629804 reaction equation
Cl[C:2]1[C:3]2[CH2:10][CH2:9][NH:8][C:4]=2[N:5]=[CH:6][N:7]=1.[F:11][C:12]1[CH:17]=[CH:16][C:15]([C:18]2[N:19]=[C:20]([CH:28]3[CH2:33][CH2:32][NH:31][CH2:30][CH2:29]3)[N:21]([CH2:23][CH2:24][N:25]([CH3:27])[CH3:26])[CH:22]=2)=[CH:14][C:13]=1[CH3:34]>>[N:5]1[C:4]2[NH:8][CH2:9][CH2:10][C:3]=2[C:2]([N:31]2[CH2:30][CH2:29][CH:28]([C:20]3[N:21]([CH2:23][CH2:24][N:25]([CH3:26])[CH3:27])[CH:22]=[C:18]([C:15]4[CH:16]=[CH:17][C:12]([F:11])=[C:13]([CH3:34])[CH:14]=4)[N:19]=3)[CH2:33][CH2:32]2)=[N:7][CH:6]=1

Participants

3

Reactant 2

HCID 457897314-Chloro-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidineHCID 90158701HCID 90158701, compound

Product 1

HCID 74766821HCID 74766821, compound

Procedure

The title compound was prepared according to the procedure described for the preparation of A4 by using 4-chloro-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidine coupling with 2-(4-(4-fluoro-3-methyl-phenyl)-2-(piperidin-4-yl)-1H-imidazol-1-yl)-N,N-dimethylethanamine. LC-MS (M+H=450, obsd.=450);

Sources & evidence

ORD record
ord-47e88687b266483eb81ac211d9497467
Source dataset
uspto-grants-2016_04
Patent number
US09315517B2

Reaction notes

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