HCID 118322699, compound → HCID 90159395, compound

Participants

Reaction Steps

The mixture of (6-{4-[4-(4-fluoro-3-trifluoromethyl-phenyl)-1-(2-pyrrolidin-1-yl-ethyl)-1H-imidazol-2-yl]-piperidin-1-yl}-5-nitro-pyrimidin-4-ylamino)-acetic acid ethyl ester (30.00 mg; 0.05 mmol; 1.00 eq.), and Pd/C (100 mg) in MeOH (10 mL) was hydrogenated under 20 psi for 2 hours. After filtration, the solvent was removed to yield (5-amino-6-{4-[4-(4-fluoro-3-trifluoromethyl-phenyl)-1-(2-pyrrolidin-1-yl-ethyl)-1H-imidazol-2-yl]-piperidin-1-yl}-pyrimidin-4-ylamino)-acetic acid ethyl ester (25 mg, 87% yield), which was used for the next reaction; LC/MS: 605 (M+H)

Provenance & Evidence