HCID 90159395, compound → HCID 74767063, compound

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Reaction Steps

The solution of (5-amino-6-{4-[4-(4-fluoro-3-trifluoromethyl-phenyl)-1-(2-pyrrolidin-1-yl-ethyl)-1H-imidazol-2-yl]-piperidin-1-yl}-pyrimidin-4-ylamino)-acetic acid ethyl ester (80.00 mg; 0.13 mmol; 1.00 eq.) in EtOH (10 mL) was refluxed for 15 hours. After reverse phase HPLC purification, 4-{4-[4-(4-fluoro-3-trifluoromethyl-phenyl)-1-(2-pyrrolidin-1-yl-ethyl)-1H-imidazol-2-yl]-piperidin-1-yl}-7,8-dihydro-5H-pteridin-6-one (55 mg, 74% yield) was obtained; LC/MS: 559 (M+H);

Provenance & Evidence