HRID629833

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID6328

Methyl iodide

CH3I

结构：CC(C)(C)[C@@]1(C)OCO[C@]23CC[C@@]4(C[C@@H]21)[C@H]1Cc2ccc(OCc5ccccc5)c5c2[C@@]4(CCN1CC1CC1)[C@H]3O5

HCID121278739

未命名化合物

PRODUCTS

生成物

结构：COc1ccc2c3c1O[C@H]1[C@@]45CC[C@@]6(C[C@@H]4[C@@](C)(C(C)(C)C)OCO5)[C@@H](C2)N(CC2CC2)CC[C@]316

HCID89985177

未命名化合物

收率 49.4%

PROCEDURE

实验过程

The title compound 8 was synthesized similar to the procedure described in Example 5 for compound 7 using methyl iodide instead of benzyl bromide. After column chromatography, 418 mg (49.4% yield) of compound 8 was isolated in a purity of 98.8% as an white solid.

WORKUP

后处理

customThe title compound 8 was synthesized similar to the procedure

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-abb6d45318e74e019807ba4c8aea29fb
来源数据集: uspto-grants-2016_04
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09315514B2
来源说明: uspto-grants-2016_04

反应 SMILES

[CH2:1]([O:8][C:9]1[C:14]2[O:15][C@H:16]3[C@@:25]45[CH2:35][CH2:36][C@:22]6([CH2:23][C@@H:24]4[C@:29]([C:31]([CH3:34])([CH3:33])[CH3:32])([CH3:30])[O:28][CH2:27][O:26]5)[C@@:17]43[CH2:18][CH2:19][N:20]([CH2:38][CH:39]3[CH2:41][CH2:40]3)[C@@H:21]6[CH2:37][C:12]([C:13]=24)=[CH:11][CH:10]=1)C1C=CC=CC=1.CI>>[C:31]([C@:29]1([CH3:30])[C@@H:24]2[C@@:25]3([CH2:35][CH2:36][C@:22]4([CH2:23]2)[C@@:17]25[C:13]6[C:12](=[CH:11][CH:10]=[C:9]([O:8][CH3:1])[C:14]=6[O:15][C@@H:16]32)[CH2:37][C@H:21]4[N:20]([CH2:38][CH:39]2[CH2:40][CH2:41]2)[CH2:19][CH2:18]5)[O:26][CH2:27][O:28]1)([CH3:34])([CH3:32])[CH3:33]