HRID629838

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：C=CCN1CC[C@]23c4c5ccc(O)c4O[C@H]2[C@@]24CC[C@]3(C[C@@H]2[C@@](C)(C(C)(C)C)OCO4)[C@H]1C5

HCID86711664

未命名化合物

结构：CC(C)(C)[C@@]1(C)OCO[C@]23CC[C@@]4(C[C@@H]21)[C@H]1Cc2ccc(OCc5ccccc5)c5c2[C@@]4(CCN1CC1CC1)[C@H]3O5

HCID121278739

未命名化合物

PRODUCTS

生成物

结构：C=CCN1CC[C@]23c4c5ccc(OCc6ccccc6)c4O[C@H]2[C@@]24CC[C@]3(C[C@@H]2[C@@](C)(C(C)(C)C)OCO4)[C@H]1C5

HCID89978738

未命名化合物

收率 98%

PROCEDURE

实验过程

The title compound 19 was synthesized similar to the procedure described in Example 5 for preparing compound 7 using compound 17 rather than 3. After column chromatography, 590 mg (98% yield) of compound 19 was isolated in a purity of 97.7% as a white solid.

WORKUP

后处理

customThe title compound 19 was synthesized similar to the procedure

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-153f953266f349adb19a26da087f7867
来源数据集: uspto-grants-2016_04
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09315514B2
来源说明: uspto-grants-2016_04

反应 SMILES

[CH2:1]([O:8][C:9]1[C:14]2[O:15][C@H:16]3[C@@:25]45[CH2:35][CH2:36][C@:22]6([CH2:23][C@@H:24]4[C@:29]([C:31]([CH3:34])([CH3:33])[CH3:32])([CH3:30])[O:28][CH2:27][O:26]5)[C@@:17]43[CH2:18][CH2:19][N:20]([CH2:38][CH:39]3C[CH2:40]3)[C@@H:21]6[CH2:37][C:12]([C:13]=24)=[CH:11][CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(N1CC[C@@]23C4C5C[C@@H]1[C@]12CC[C@]2(OCO[C@@](C(C)(C)C)(C)[C@H]2C1)[C@@H]3OC=4C(O)=CC=5)C=C>>[CH2:38]([N:20]1[CH2:19][CH2:18][C@@:17]23[C:13]4[C:12]5[CH2:37][C@@H:21]1[C@:22]12[CH2:36][CH2:35][C@:25]2([O:26][CH2:27][O:28][C@@:29]([C:31]([CH3:34])([CH3:33])[CH3:32])([CH3:30])[C@H:24]2[CH2:23]1)[C@@H:16]3[O:15][C:14]=4[C:9]([O:8][CH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1)=[CH:10][CH:11]=5)[CH:39]=[CH2:40]