2-(4-Hydroxy-2,3-dimethyl-phenyl)-cyclopropanecarboxylic acid ethyl ester → HCID 74221671, compound

HRID 62985Notes

Reaction equation

HRID 62985 reaction equation
Cl[CH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[C:5]([S:9][CH:10]([CH3:12])[CH3:11])[N:4]=1.C([O:15][C:16]([CH:18]1[CH2:20][CH:19]1[C:21]1[CH:26]=[CH:25][C:24]([OH:27])=[C:23]([CH3:28])[C:22]=1[CH3:29])=[O:17])C>>[CH:10]([S:9][C:5]1[N:4]=[C:3]([CH2:2][O:27][C:24]2[CH:25]=[CH:26][C:21]([CH:19]3[CH2:20][CH:18]3[C:16]([OH:17])=[O:15])=[C:22]([CH3:29])[C:23]=2[CH3:28])[CH:8]=[CH:7][CH:6]=1)([CH3:12])[CH3:11]

Participants

3

Reactant 2

HCID 901180052-(4-Hydroxy-2,3-dimethyl-phenyl)-cyclopropanecarboxylic acid ethyl esterHCID 901181412-Chloromethyl-6-isopropylsulfanyl-pyridine

Product 1

HCID 74221671HCID 74221671, compoundYield 83.1%

Procedure

2-Chloromethyl-6-isopropylsulfanyl-pyridine (0.030 g, 0.149 mmol) obtained in Step C of Preparation Example 16 and 2-(4-hydroxy-2,3-dimethyl-phenyl)-cyclopropane carboxylic acid ethyl ester (0.035 g, 0.149 mmol) obtained in Step C of Preparation Example 48 were used to react sequentially in the same manner as in Steps A and B of Example 1 to obtain the title compound (0.046 g, 83%).

Workup

  1. customto react sequentially in the same manner as in Steps A and B of Example 1

Sources & evidence

ORD record
ord-8f1f7bf5888d4b1898d637471491ae02
Source dataset
uspto-grants-2016_09
Patent number
US09447044B2

Reaction notes

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