3-Chloromethyl-2-isopropylsulfanyl-pyridine → 2-[3,5-Difluoro-4-(2-isopropylsulfanyl-pyridin-3-ylmethoxy)-benzyl]-cyclopropane carboxylic acid

Participants

Reaction Steps

3-Chloromethyl-2-isopropylsulfanyl-pyridine (0.019 g, 0.09 mmol) obtained in Step C of Preparation Example 1 and 2-(3,5-difluoro-4-hydroxy-benzyl]-cyclopropane carboxylic acid ethyl ester (0.023 g, 0.09 mmol) obtained in Step D of Preparation Example 49 were used to react sequentially in the same manner as in Steps A and B of Example 1 to obtain the title compound (0.028 g, 75%).

Provenance & Evidence