化工社化工社 化学情報印刷レポート · 研究参考用
HCID 59455564、化合物 → 2-[3,5-Difluoro-4-(2-propylsulfanyl-pyridin-3-ylmethoxy)-benzyl]-cyclopropane carboxylic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | HCID 59455564 | HCID 59455564 | — |
| 反応物 | 3-Chloromethyl-2-propylsulfanyl-pyridine | HCID 90118282 | — |
| 生成物 | 2-[3,5-Difluoro-4-(2-propylsulfanyl-pyridin-3-ylmethoxy)-benzyl]-cyclopropane carboxylic acid | HCID 74221759 | 77% |
反応手順
3-chloromethyl-2-propylsulfanyl-pyridine (0.016 g, 0.08 mmol) obtained in Step C of Preparation Example 14 and 2-(3,5-difluoro-4-hydroxy-benzyl]-cyclopropane carboxylic acid ethyl ester (0.02 g, 0.08 mmol) obtained in Step D of Preparation Example 49 were used to react sequentially in the same manner as in Steps A and B of Example 1 to obtain the title compound (0.024 g, 77%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09447044B2 |
| 出典データセット | uspto-grants-2016_09 |
| ORD ID | ord-49acaabdf6b64ff9bf95cbf4cbc426d4 |
| 出典メモ | uspto-grants-2016_09 |