HCID 71136196, compound → HCID 71117262, compound

Participants

Reaction Steps

To a round bottom flask containing tert-butyl 5-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]-3,6-dihydropyridine-1(2H)-carboxylate (17-27) (1 g, 2.497 mmol), was added EtOH (25 mL) & Palladium on Carbon (10% by weight on carbon) (0.25 g, 0.2349 mmol). A balloon containing hydrogen gas was then attached and purged 3× with vacuum/hydrogen. The reaction mixture was permitted to stir at room temperature for 1 hour, then purged 3× with vacuum/nitrogen, diluted with EtOH, filtered & concentrated to yield tert-butyl 3-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]piperidine-1-carboxylate (18-1). LRMS (M+H)+: observed=403.3, calculated=403.5.

Provenance & Evidence