4-[1-(2,2-Dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]butanenitrile → 5-(4-Aminobutyl)-1-(2,2-dimethylpropyl)-3-methyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one

Participants

Reaction Steps

To a mixture of Raney nickel (1 mL) in ethanol 2M NH3 solution (5 mL) under nitrogen was added 38-1 (0.40 g, 1.40 mmol) dissolved in ethanol (1 mL). The mixture was flushed with hydrogen and stirred overnight under a hydrogen filled balloon. The solution was filtered through a syringe and the filtrate was concentrated to give 38-2. (0.41 g, 100%). LRMS (ES) (M+H)+: observed=291.2, calculated=291.4.

Provenance & Evidence