HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Chloromethyl-2-cyclopentylsulfanyl-pyridine → [6-(2-Cyclopentylsulfanyl-pyridin-3-ylmethoxy)-5,7-difluoro-benzofuran-3-yl]-acetic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Chloromethyl-2-cyclopentylsulfanyl-pyridine | HCID 90118283 | — |
| Reactant | (5,7-Difluoro-6-hydroxy-benzofuran-3-yl)-acetic acid methyl ester | HCID 90118454 | — |
| Product | [6-(2-Cyclopentylsulfanyl-pyridin-3-ylmethoxy)-5,7-difluoro-benzofuran-3-yl]-acetic acid | HCID 74221758 | 83.4% |
Reaction Steps
3-Chloromethyl-2-cyclopentylsulfanyl-pyridine (19 mg, 0.08 mmol) obtained in Step C of Preparation Example 8 and (5,7-difluoro-6-hydroxy-benzofuran-3-yl)-acetic acid methyl ester (20 mg, 0.08 mmol) obtained in Step C of Preparation Example 50 were used to react sequentially in the same manner as in Steps A and B of Example 1 to obtain the title compound (28 mg, 81%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09447044B2 |
| Source dataset | uspto-grants-2016_09 |
| ORD ID | ord-254664723cbf40aab998a12b8caa5964 |
| Source note | uspto-grants-2016_09 |