反应详情

To a solution of ethyl (2-amino-6-(2-methoxyethoxy)-3-nitropyridin-4-yl)(4-((diethoxyphosphoryl)methyl)benzyl)carbamate (1 equiv.) in EtOH (0.05 M) was added 10% Pd/C (50% equiv. by weight) in a Paar Shaker Flask. The reaction mixture was placed in a Paar Shaker at 55 psi for 4 h. At this point the reaction mixture was passed through a pad of Celite, washing with a 2:1 mixture of CHCl3:MeOH. The combined organic layers were dried over anhydrous Na2SO4 and the volatiles were removed in vacuo. The resulting residue was used in the next step without further purification.

1. washwashing with a 2:1 mixture of CHCl3
2. dry with materialThe combined organic layers were dried over anhydrous Na2SO4
3. customthe volatiles were removed in vacuo
4. customThe resulting residue was used in the next step without further purification