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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 629950Generated: October 27, 2026

Triethyl Phosphate → Diethyl 2-(2-(2-iodoethoxy)ethoxy)ethylphosphonate

https://huagongshe.com/reaction/629950

Reaction equation

Participants

RoleNameHCIDCharge
ReactantTriethyl PhosphateHCID 6535—
Reactant1,2-Bis(2-iodoethoxy)ethaneHCID 593436—
ProductDiethyl 2-(2-(2-iodoethoxy)ethoxy)ethylphosphonateHCID 86667775—

Reaction Conditions

Temperature160 °C

Reaction Steps

1,2-bis(2-iodoethoxy)ethane (1.0 eq) was mixed with triethyl phosphate (1 eq) then heated to 160° C. for 20 minutes by microwave. The crude mixture was purified by flash chromatography on a COMBIFLASH™ system using 85-100% EtOAc/Hex to give diethyl 2-(2-(2-iodoethoxy)ethoxy)ethylphosphonate as a colorless oil.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09315530B2
Source datasetuspto-grants-2016_04
ORD IDord-f3818b3ad7954ee0826a221853dbe838
Source noteuspto-grants-2016_04