1,4-Dioxane hydrochloride → HCID 178429473, compound

HRID 629968Notes

Reaction equation

HRID 629968 reaction equation
[NH2:1][C:2]1[CH:3]=[CH:4][C:5]([Cl:18])=[C:6]([CH2:8][S:9][C:10]2[N:15]=[C:14]([OH:16])[CH:13]=[C:12]([CH3:17])[N:11]=2)[CH:7]=1.Cl.O1CCOCC1>CO>[ClH:18].[NH2:1][C:2]1[CH:3]=[CH:4][C:5]([Cl:18])=[C:6]([CH2:8][S:9][C:10]2[N:15]=[C:14]([OH:16])[CH:13]=[C:12]([CH3:17])[N:11]=2)[CH:7]=1

Participants

4

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 178429472HCID 178429472, compound

Product 1

HCID 178429473HCID 178429473, compoundYield 196.4%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of 2-{[(5-amino-2-chlorophenyl)methyl]sulfanyl}-6-methylpyrimidin-4-ol (45 mg, 0.16 mmol) in MeOH (2 mL) was added 4 M HCl/dioxane (1 mL, 4.0 mmol). The mixture was evaporated and dried in vacuo, affording the title compound (50 mg, 98% yield); 1H NMR (400 MHz, DMSO-d6): δ 2.23 (s, 3H), 4.50 (s, 2H), 6.01 (s, 1H), 7.19 (d, 1H, J=7.4 Hz), 7.50 (m, 2H); M+282.

Workup

  1. customThe mixture was evaporated
  2. customdried in vacuo

Sources & evidence

ORD record
ord-19784cecbb264ae99a731a120dc4731e
Source dataset
uspto-grants-2016_04
Patent number
US09315521B2

Reaction notes

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