1,4-Dioxane hydrochloride → HCID 178429444, compound

Participants

Reaction Steps

To a solution of 2-{[(2-chloropyridin-3-yl)methyl]sulfanyl}-6-methylpyrimidin-4-ol (400 mg, 1.5 mmol) in MeOH (5 mL) was added 4 M HCl/dioxane (2 mL, 8.0 mmol). The mixture was evaporated and dried in vacuo, affording the title compound (416 mg, 91% yield); 1H NMR (400 MHz, DMSO-d6): δ 2.20 (s, 3H), 4.42 (s, 2H), 6.05 (s, 1H), 7.39 (td, 1H, J=2.7 Hz, 7.4 Hz), 8.05 (dd, 1H, J=2.0 Hz, 7.6 Hz), 8.30 (dd, 1H, J=2.0 Hz, 6.7 Hz); M−266.

Provenance & Evidence