HuagongsheHuagongshe Chemistry Print Report · For research reference only
Formaldehyde → (3-chloro-2H-indazol-2-yl)methanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Formaldehyde | HCID 712 | — |
| Reactant | 3-Chloro-1H-indazole | HCID 95894 | — |
| Solvent | Water | HCID 962 | — |
| Product | (3-chloro-2H-indazol-2-yl)methanol | HCID 59589510 | 99.7% |
Reaction Steps
In a 250 mL round bottom flask, 3-chloro-2H-indazole (1.95 g, 10 mmol), 30% HCHO (2 mL, 20 mmol) were mixed in water (10 mL). The reaction mixture was refluxed for 2 hours. After cooling down to room temperature, the solid was filtered, washed with water, and dried under vacuum to provide (3-chloro-2H-indazol-2-yl)methanol (1.82 g, 99% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09315521B2 |
| Source dataset | uspto-grants-2016_04 |
| ORD ID | ord-df448b7d99c644bc9ce7349e01de42a3 |
| Source note | uspto-grants-2016_04 |