1,4-Dioxane hydrochloride → HCID 178462653, compound

Participants

Reaction Steps

To a mixture of 2-({[2-chloro-6-(4-ethylpiperazin-1-yl)phenyl]methyl}sulfanyl)-6-methylpyrimidin-4-ol (500 mg, 1.3 mmol) in MeOH (10 mL) was added 4 M HCl/dioxane (2 mL, 8 mmol). The mixture was stirred for 15 minutes, evaporated, and dried in vacuo, affording the title compound (575 mg, 98% yield); 1H NMR (400 MHz, DMSO-d6): δ 1.26 (t, 3H, J=7.2 Hz), 2.24 (s, 3H), 3.15 (m, 6H), 3.22 (d, 2H, J=11.3 Hz), 3.49 (d, 2H, J=11.7 Hz), 4.67 (s, 2H), 6.11 (s, 1H), 7.19 (dd, 1H, J=1.2 Hz, 7.8 Hz), 7.29 (dd, 1H, J=1.2 Hz, 7.8 Hz), 7.34 (t, 1H, J=8.0 Hz); M+379.

Provenance & Evidence