1,4-Dioxane hydrochloride → HCID 178462643, compound

HRID 630049Notes

Reaction equation

HRID 630049 reaction equation
[CH2:1]([N:3]1[CH:7]=[CH:6][N:5]=[C:4]1[CH2:8][S:9][C:10]1[N:15]=[C:14]([OH:16])[CH:13]=[C:12]([CH3:17])[N:11]=1)[CH3:2].[ClH:18].O1CCOCC1>CO>[ClH:18].[ClH:18].[CH2:1]([N:3]1[CH:7]=[CH:6][N:5]=[C:4]1[CH2:8][S:9][C:10]1[N:15]=[C:14]([OH:16])[CH:13]=[C:12]([CH3:17])[N:11]=1)[CH3:2]

Participants

4

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 178462642HCID 178462642, compound

Product 1

HCID 178462643HCID 178462643, compoundYield 99%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a mixture of 2-{[(1-ethyl-1H-imidazol-2-yl)methyl]sulfanyl}-6-methylpyrimidin-4-ol (215 mg, 0.86 mmol) in MeOH (3 mL) was added 4 M HCl/dioxane (2 mL, 8.0 mmol). The mixture became clear, and a solid precipitated. The solvent was evaporated. The solid product was dried in vacuo, affording the title compound (275 mg, 99% yield); 1H NMR (400 MHz, DMSO-d6): δ 1.38 (t, 3H, J=7.2 Hz), 2.16 (s, 3H), 4.29 (m, 2H), 4.73 (s, 2H), 6.17 (s, 1H), 7.61 (d, 1H, J=2.0 Hz), 7.15 (d, 1H, J=2.0 Hz); M+251.

Workup

  1. customa solid precipitated
  2. customThe solvent was evaporated
  3. customThe solid product was dried in vacuo

Sources & evidence

ORD record
ord-7c89f5053c72442d9b97d10f1a452f54
Source dataset
uspto-grants-2016_04
Patent number
US09315521B2

Reaction notes

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