Hydrochloric Acid → HCID 178464162, compound

Participants

Reaction Steps

3-chloro-N,N-diethyl-4-{[(4-hydroxy-6-methylpyrimidin-2-yl)sulfanyl]methyl}benzene-1-carboximidamide (83 mg, 227 μmol) was stirred in methanol (10 mL), and a solution of 4 N HCl in dioxane (170 μL, 681 μmol) was added dropwise at 0° C. The mixture was stirred for 1.5 hours at room temperature. The solvent was removed by evaporation, and the residue was triturated with diethyl ether and dried in vacuo to afford to 3-chloro-N,N-diethyl-4-{[(4-hydroxy-6-methylpyrimidin-2-yl)sulfanyl]methyl}benzene-1-carboximidamide dihydrochloride (80 mg, 81% yield); 1H NMR (400 MHz, DMSO-d6): δ 1.15 (t, J=7.2 Hz, 6H), 2.21 (s, 3H), 2.84-2.93 (m, 4H), 4.51 (s, 2H), 6.04 (bs, 1H), 7.51-7.54 (m, 1H), 7.81-7.84 (m, 2H); LRMS (ES+) m/z 365 (100%, M+1).

Provenance & Evidence