Hydrochloric Acid → HCID 178429509, compound

Participants

Reaction Steps

6-methyl-2-{[(1-methyl-1H-imidazol-5-yl)methyl]sulfanyl}pyrimidin-4-ol, (252 mg, 1.1 mmol) was stirred in methanol (30 mL), and a solution of 4N HCl in dioxane (400 μL, 1.6 mmol) was added dropwise at 0° C. The mixture was stirred for 1 hour at room temperature. The solvent was removed by evaporation, and the residue was triturated with diethyl ether and dried in vacuo to afford to 6-methyl-2-{[(1-methyl-1H-imidazol-5-yl)methyl]sulfanyl}pyrimidin-4-ol hydrochloride (281 mg, 96% yield); 1H NMR (400 MHz, DMSO-d6): δ 2.24 (s, 3H), 3.88 (s, 3H), 4.50 (s, 2H), 6.15 (bs, 1H), 7.65 (s, 1H), 9.09 (s, 1H); LRMS (ES+) m/z 237 (70%, M+1).

Provenance & Evidence