Hydrochloric Acid → HCID 178462564, compound

Participants

Reaction Steps

2-{[(1-ethyl-1H-pyrazol-3-yl)methyl]sulfanyl}-6-methylpyrimidin-4-ol (221 mg, 881 μmol) was stirred in methanol (30 mL) and a solution of 4 N HCl in dioxane (330 μL, 1.3 mmol) was added dropwise at 0° C. The mixture was stirred for 30 minutes at room temperature. The solvent was removed by evaporation, and the residue was triturated with diethyl ether and dried in vacuo to afford 2-{[(1-ethyl-1H-pyrazol-3-yl)methyl]sulfanyl}-6-methylpyrimidin-4-ol hydrochloride (243 mg, 96% yield); 1H NMR (400 MHz, DMSO-d6): δ 1.34 (t, J=7.3 Hz, 3H), 2.25 (s, 3H), 4.08 (q, J=7.3 Hz, 2H), 4.36 (s, 2H), 6.13 (s, 1H), 6.22 (d, J=2.2 Hz, 1H), 7.66 (d, J=2.2 Hz, 1H); LRMS (ES+) m/z 251 (75%, M+1).

Provenance & Evidence