Hydrochloric Acid → HCID 178429501, compound

Participants

Reaction Steps

2-{[(1,2-dimethyl-1H-imidazol-5-yl)methyl]sulfanyl}-6-methylpyrimidin-4-ol (390 mg, 1.6 mmol) was stirred in methanol (50 mL), and a solution of 4 N HCl in dioxane (580 μL, 2.3 mmol) was added dropwise at 0° C. The mixture was stirred for 30 minutes at room temperature. The solvent was removed by evaporation, and the residue was triturated with diethyl ether and dried in vacuo to afford 2-{[(1,2-dimethyl-1H-imidazol-5-yl)methyl]sulfanyl}-6-methylpyrimidin-4-ol hydrochloride (412 mg, 92% yield); 1H NMR (400 MHz, DMSO-d6): δ 2.23 (s, 314), 2.55 (s, 3H), 3.68 (s, 3H), 4.48 (s, 2H), 6.12 (s, 1H), 7.51 (s, 1H); LRMS (ES+) m/z 251 (100%, M+1).

Provenance & Evidence