Hydrochloric Acid → HCID 178429514, compound

Participants

Reaction Steps

6-methyl-2-{[(2-methyl-1,3-thiazol-4-yl)methyl]sulfanyl}pyrimidin-4-ol (200 mg, 790 μmol) was stirred in methanol (25 mL), and a solution of 4 N HCl in dioxane (300 μL, 1.2 mmol) was added dropwise at 0° C. The mixture was stirred for 30 minutes at room temperature. The solvent was removed by evaporation, and the residue was triturated with diethyl ether and dried in vacuo to afford 6-methyl-2-{[(2-methyl-1,3-thiazol-4-yl)methyl]sulfanyl}pyrimidin-4-ol hydrochloride (230 mg, 100% yield); 1H NMR (400 MHz, DMSO-d6): δ 2.22 (s, 3H), 2.64 (s, 3H), 4.44 (s, 2H), 6.10 (bs, 1H), 7.46 (s, 1H); LRMS (ES+) m/z 254 (100%, M+1).

Provenance & Evidence