1,4-Dioxane hydrochloride → HCID 178429535, compound

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Reaction Steps

To a mixture of 6-methyl-2-{[(4-methyl-1,3-thiazol-5-yl)methyl]sulfanyl}pyrimidin-4-ol (500 mg, 2.0 mmol) in MeOH (5 mL) was added 4 M HCl/dioxane (2 mL, 8.0 mmol). The solution was evaporated and dried in vacuo, affording the title compound (213 mg, 99% yield); 1H NMR (400 MHz, DMSO-d6): δ 2.26 (s, 3H), 2.44 (s, 3H), 4.58 (s, 2H), 6.08 (s, 1H), 9.10 (s, 1H); M+254.

Provenance & Evidence