1,4-Dioxane hydrochloride → HCID 178462826, compound

HRID 630124Notes

Reaction equation

HRID 630124 reaction equation
[CH2:1]([N:3]1[C:7]([CH3:8])=[C:6]([CH2:9][S:10][C:11]2[N:16]=[C:15]([OH:17])[CH:14]=[C:13]([CH3:18])[N:12]=2)[N:5]=[CH:4]1)[CH3:2].[ClH:19].O1CCOCC1>CO>[ClH:19].[CH2:1]([N:3]1[C:7]([CH3:8])=[C:6]([CH2:9][S:10][C:11]2[N:16]=[C:15]([OH:17])[CH:14]=[C:13]([CH3:18])[N:12]=2)[N:5]=[CH:4]1)[CH3:2]

Participants

4

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 178462825HCID 178462825, compound

Product 1

HCID 178462826HCID 178462826, compoundYield 99%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a mixture of 2-{[(1-ethyl-5-methyl-1H-imidazol-4-yl)methyl]sulfanyl}-6-methylpyrimidin-4-ol (60 mg, 0.23 mmol) in MeOH (2 mL) was added 4 M HCl/dioxane (500 μL, 2.0 mmol). The mixture was filtered to remove particles in suspension. The solution was evaporated and dried in vacuo, affording the title compound (68 mg, 99% yield); 1H NMR (400 MHz, DMSO-d6): δ 1.38 (t, 3H, J=6.7 Hz), 2.23 (s, 3H), 2.38 (s, 3H), 4.09 (m, 2H), 4.44 (s, 2H), 6.09 (s, 1H), 9.04 (s, 1H); M+266.

Workup

  1. filtrationThe mixture was filtered
  2. customto remove particles in suspension
  3. customThe solution was evaporated
  4. customdried in vacuo

Sources & evidence

ORD record
ord-df61981ea975459c90c061975daaaebb
Source dataset
uspto-grants-2016_04
Patent number
US09315521B2

Reaction notes

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