4-(Chloromethyl)-1-methyl-1H-imidazole → HCID 178429502, compound

HRID 630163Notes

Reaction equation

HRID 630163 reaction equation
Cl[CH2:2][C:3]1[N:4]=[CH:5][N:6]([CH3:8])[CH:7]=1.[CH3:9][C:10]1[N:15]=[C:14]([SH:16])[N:13]=[C:12]([OH:17])[CH:11]=1>>[CH3:9][C:10]1[N:15]=[C:14]([S:16][CH2:2][C:3]2[N:4]=[CH:5][N:6]([CH3:8])[CH:7]=2)[N:13]=[C:12]([OH:17])[CH:11]=1

Participants

3

Reactant 2

HCID 121474884-(Chloromethyl)-1-methyl-1H-imidazoleHCID 178429541HCID 178429541, compound

Product 1

HCID 178429502HCID 178429502, compoundYield 60%

Procedure

This example was synthesized from 4-(chloromethyl)-1-methyl-1H-imidazole and 6-methyl-2-sulfanylpyrimidin-4-ol following the general procedure as shown in the last step of Example 109. This provided the title compound as a white solid (260 mg, 60% yield); 1H NMR (400 MHz, DMSO-d6): δ 2.19 (s, 3H), 3.60 (s, 3H), 4.24 (s, 2H), 5.97 (bs, 1H), 7.06 (s, 1H), 7.52 (s, 1H); M+237.

Sources & evidence

ORD record
ord-5b06d7ef11c440df8cb6ef5668e9e7e0
Source dataset
uspto-grants-2016_04
Patent number
US09315521B2

Reaction notes

Loading…