4-(Bromomethyl)-3,5-dichloropyridine → HCID 178516146, compound

HRID 630167Notes

Reaction equation

HRID 630167 reaction equation
[SH:1][C:2]1[N:7]=[C:6]([OH:8])[CH:5]=[C:4]([C:9]([F:12])([F:11])[F:10])[N:3]=1.Br[CH2:14][C:15]1[C:20]([Cl:21])=[CH:19][N:18]=[CH:17][C:16]=1[Cl:22]>>[Cl:22][C:16]1[CH:17]=[N:18][CH:19]=[C:20]([Cl:21])[C:15]=1[CH2:14][S:1][C:2]1[N:7]=[C:6]([OH:8])[CH:5]=[C:4]([C:9]([F:12])([F:10])[F:11])[N:3]=1

Participants

3

Reactant 2

HCID 222277664-(Bromomethyl)-3,5-dichloropyridineHCID 178516148HCID 178516148, compound

Product 1

HCID 178516146HCID 178516146, compound

Procedure

This example was synthesized from 2-sulfanyl-6-(trifluoromethyl)pyrimidin-4-ol and 4-(bromomethyl)-3,5-dichloropyridine by following general procedure as described in the last step of Example 22. The title compound was obtained as a white solid (660 mg, 37% yield); 1H NMR (400 MHz, DMSO-d6): δ 4.72 (s, 2H), 6.69 (br, 1H), 8.64 (s, 2H); M+356.

Sources & evidence

ORD record
ord-ac74e3f0775b467290cd82c6a35960e2
Source dataset
uspto-grants-2016_04
Patent number
US09315521B2

Reaction notes

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