Hydrochloric Acid → HCID 178429505, compound

Participants

Reaction Steps

2-{[(1-cyclohexyl-1H-imidazol-5-yl)methyl]sulfanyl)-6-methylpyrimidin-4-ol (300 mg, 986 μmol) was stirred in methanol (30 mL), and a solution of 4 N HCl in dioxane (370 μL, 1.5 mmol) was added dropwise at 0° C. The mixture was stirred for 30 minutes at room temperature. The solvent was removed by evaporation, and the residue was triturated with diethyl ether and dried in vacuo to afford 2-{[(1-cyclohexyl-1H-imidazol-5-yl)methyl]sulfanyl)-6-methylpyrimidin-4-ol hydrochloride (330 mg, 98% yield); 1H NMR (500 MHz, DMSO-d6): δ 1.15-2.05 (m, 10H), 2.22 (s, 3H). 4.28-4.36 (m, 1H), 4.58 (s, 2H), 6.14 (s, 1H), 7.64 (s, 1H), 9.32 (s, 1H); LRMS (ES+) m/z 305 (100%, M+1).

Provenance & Evidence