反应详情

A mixture of methyl 2-chloro-6-methylbenzoate (3.0 g, 16.2 mmol), N-bromosuccinimide (3.0 g, 17.0 mmol), and benzoyl peroxide (catalytic) in anhydrous carbon tetrachloride (50 mL) was stirred at reflux overnight. Dichloromethane (50 mL) was added after cooling to room temperature. The mixture was extracted with 1 N NaOH (2×100 mL). The organic layer was recovered, dried over MgSO4, filtered, and evaporated, and the residue was dried in vacuo, affording methyl 2-(bromomethyl)-6-chlorobenzoate (4.06 g, 95% yield), which was used without further purification.

1. temperatureat reflux overnight
2. extractionThe mixture was extracted with 1 N NaOH (2×100 mL)
3. customThe organic layer was recovered
4. dry with materialdried over MgSO4
5. filtrationfiltered
6. customevaporated
7. customthe residue was dried in vacuo