Hydrochloric Acid → HCID 178429492, compound

Participants

Reaction Steps

6-methyl-2-[(quinoxalin-2-ylmethyl)sulfanyl]pyrimidin-4-ol (250 mg, 879 μmol) was stirred in methanol (25 mL) and a solution of 4 N HCl in dioxane (660 μL, 2.63 mmol) was added dropwise at 0° C. The mixture was stirred for 20 minutes at room temperature. The solvent was removed by evaporation, and the residue was triturated with diethyl ether, filtered, washed with ether, and dried in vacuo to afford 6-methyl-2-[(quinoxalin-2-ylmethyl)sulfanyl]pyrimidin-4-ol dihydrochloride (289 mg, 92% yield); 1H NMR (400 MHz, DMSO-d6): δ 2.20 (s, 3H), 4.74 (s, 2H), 6.10 (s, 1H), 7.82-7.89 (m, 2H), 8.03-8.11 (m, 2H), 9.12 (s, 1H); LRMS (ES+) m/z 285 (100%, M+1).

Provenance & Evidence