Ethyl Acetate → 2-(3',4',5'-Trimethoxy-[1,1'-biphenyl]-4-yl)benzo[d]oxazole-5-amine

Participants

Reaction Steps

22 mg (0.0541 mmol) of 5-nitro-2-(3′,4′,5′-trimethoxy-[1,1′-biphenyl]-4-yl)benzo[d]oxazol e was dissolved in methanol, and then, 10% Pd/C was added thereto under hydrogen gas atmosphere. The mixed solution was stirred for 4 hours, and ethyl acetate was added thereto to filter with a celite pad. The filtered solution was concentrated under reduced pressure. Afterwards, the reaction solution was subjected to a silica gel column chromatography (ethyl acetate/normal-hexane at a volume ratio of 1:1) to obtain 15.2 mg (yield=74.6%) of 2-(3′,4′,5′-trimethoxy-[1,1′-biphenyl]-4-yl)benzo[d]oxazole-5-amine (Derivative #7).

Provenance & Evidence