Phosphorus tribromide → HCID 66820733, compound

HRID 630290Notes

Reaction equation

HRID 630290 reaction equation
[CH:1]([C:3]1[N:4]=[CH:5][S:6][C:7]=1[CH2:8]O)=[CH2:2].[Br:10]P(Br)Br>ClCCl>[BrH:10].[Br:10][CH2:8][C:7]1[S:6][CH:5]=[N:4][C:3]=1[CH:1]=[CH2:2]

Participants

4

Reactant 2

HCID 24614Phosphorus tribromideHCID 59589417HCID 59589417, compound

Product 1

HCID 66820733HCID 66820733, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of (4-ethenyl-1,3-thiazol-5-yl)methanol (370 mg, 2.6 mmol) in anhydrous dichloromethane (20 mL) was added dropwise tribromophosphane (275 uL, 2.9 mmol). The mixture was stirred at room temperature for 3 hours. Dichloromethane was evaporated, and the residue was dried in vacuo to afford 5-(bromomethyl)-4-ethenyl-1,3-thiazole hydrobromide. The product was used without further purification.

Workup

  1. customDichloromethane was evaporated
  2. customthe residue was dried in vacuo

Sources & evidence

ORD record
ord-588c1ad47c334d658a450a94cc9e0851
Source dataset
uspto-grants-2016_04
Patent number
US09315521B2

Reaction notes

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