Phosphorus tribromide → 1256562-26-1

HRID 630296Notes

Reaction equation

HRID 630296 reaction equation
[CH3:1][C:2]1[N:3]=[CH:4][S:5][C:6]=1[CH2:7]O.[Br:9]P(Br)Br>ClCCl>[BrH:9].[Br:9][CH2:7][C:6]1[S:5][CH:4]=[N:3][C:2]=1[CH3:1]

Participants

4

Reactant 2

HCID 24614Phosphorus tribromideHCID 10329317(4-Methyl-1,3-thiazol-5-yl)methanol

Product 1

HCID 668206651256562-26-1

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of (4-methyl-1,3-thiazol-5-yl)methanol (2.5 g, 19.4 mmol) in anhydrous dichloromethane (100 mL) was added dropwise tribromophosphane (2.00 mL, 21.3 mmol). The mixture was stirred at room temperature for 3.5 hours. Dichloromethane was evaporated, and the residue was then dried in vacuo, affording 5-(bromomethyl)-4-methyl-1,3-thiazole hydrobromide. The product was used for the next step without further purification.

Workup

  1. customDichloromethane was evaporated
  2. customthe residue was then dried in vacuo

Sources & evidence

ORD record
ord-c86e13684b824846a87c7009db576e56
Source dataset
uspto-grants-2016_04
Patent number
US09315521B2

Reaction notes

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