HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 8-Azabicyclo(3.2.1)octan-3-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 1,4-Dioxane | HCID 31275 | — |
| Reactant | tert-butyl (1R,5S)-3-oxo-8-azabicyclo[3.2.1]octane-8-carboxylate | HCID 688612 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 8-Azabicyclo(3.2.1)octan-3-one | HCID 434453 | 128.2% |
Reaction Steps
A solution of N-Boc nortropinone (0.73 g, 3.24 mmol) in a minimal amount of dichloromethane (1 mL) was treated with a solution of 4 M hydrochloric acid in dioxane (3.2 mL, 12.8 mmol). After stirring for 2.5 days, the reaction was complete by TLC analysis. Solvent was removed under reduced pressure to give 0.52 g of 8-azabicyclo[3.2.1]octan-3-one.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09315509B2 |
| Source dataset | uspto-grants-2016_04 |
| ORD ID | ord-24d9a5ac72d848cfaefda865ca8509e2 |
| Source note | uspto-grants-2016_04 |