HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl 4-Amino-3-chlorobenzoate → (4-Amino-3-chlorophenyl)methanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl 4-Amino-3-chlorobenzoate | HCID 1515284 | — |
| Reactant | Aluminium lithium hydride | HCID 21226445 | — |
| Reactant | (4-Amino-5-chloro-2-methoxyphenyl)methanol | HCID 55277042 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | (4-Amino-3-chlorophenyl)methanol | HCID 13843958 | — |
Reaction Steps
Obtained as a light brown solid (76%) starting from commercially available methyl 4-amino-3-chlorobenzoate (4 g; 0.021 mol) and lithium aluminium hydride (1.09 g; 0.028 mol) in 144 ml tetrahydrofuran following the experimental procedure as described for intermediate 38.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09315463B2 |
| Source dataset | uspto-grants-2016_04 |
| ORD ID | ord-3ac020c2dd284d98b86967f778435863 |
| Source note | uspto-grants-2016_04 |