HuagongsheHuagongshe Chemistry Print Report · For research reference only
Imidazole → 4-({[Tert-butyl(dimethyl)silyl]oxy}methyl)-2-chloroaniline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Imidazole | HCID 795 | — |
| Reactant | tert-Butyldimethylsilyl chloride | HCID 28928 | — |
| Reactant | (4-Amino-3-chlorophenyl)methanol | HCID 13843958 | — |
| Reactant | 4-({[Tert-butyl(dimethyl)silyl]oxy}methyl)-2-chloro-5-methoxyaniline | HCID 67145657 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 4-({[Tert-butyl(dimethyl)silyl]oxy}methyl)-2-chloroaniline | HCID 67145295 | — |
Reaction Steps
Obtained as a light orange oil (87%) starting from (4-Amino-3-chlorophenyl)methanol (intermediate 45; 2.72 g, 0.016 mol), 4.94 g (0.033 mmol) of cloro(tertbutyl)-dimethylsilane and 3.35 g (0.049 mol) of imidazole in 68 ml DMF and following the experimental procedure as described for intermediate 39.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09315463B2 |
| Source dataset | uspto-grants-2016_04 |
| ORD ID | ord-e5fdf61f8e9145a99cc6dba5d126698a |
| Source note | uspto-grants-2016_04 |