HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acryloyl chloride → N-[4-({[tert-butyl(dimethyl)silyl]oxy}methyl)-2-chlorophenyl]acrylamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acryloyl chloride | HCID 13140 | — |
| Reactant | N,N-Diethyl-2-propanamine | HCID 521913 | — |
| Reactant | N-[4-({[tert-butyl(dimethyl)silyl]oxy}methyl)-2-chloro-5-methoxyphenyl]-acrylamide | HCID 67145019 | — |
| Reactant | 4-({[Tert-butyl(dimethyl)silyl]oxy}methyl)-2-chloroaniline | HCID 67145295 | — |
| Product | N-[4-({[tert-butyl(dimethyl)silyl]oxy}methyl)-2-chlorophenyl]acrylamide | HCID 67145162 | — |
Reaction Steps
Obtained as a white crystalline solid (77%) starting from 4-({[tert-butyl(dimethyl)silyl]-oxy}methyl)-2-chloroaniline (intermediate 46; 2 g; 7.36 mmol), acryloyl chloride (0.78 ml; 9.56 mmol) and diethylisopropylamine (1.92 ml, 11.04 mmol) following the experimental procedure as described for intermediate 40.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09315463B2 |
| Source dataset | uspto-grants-2016_04 |
| ORD ID | ord-69d900b995554216b9739ce078fcee42 |
| Source note | uspto-grants-2016_04 |