HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HCID 178483938, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | HCID 178483939 | HCID 178483939 | — |
| Reactant | HCID 178493272 | HCID 178493272 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 178483938 | HCID 178483938 | — |
Reaction Steps
Obtained as a beige foam (91%) starting from trans-4-((3-(4-((tert-butyl(dimethyl)-silyloxy)methyl)-2-chlorophenylamino)-3-oxopropyl)(methyl)amino)-cyclohexylhydroxy-(di-2-thienyl)acetate (intermediate 48; 433 mg, 0.64 mmol) and 1M hydrochloric acid (1.9 ml; 1.9 mmol) in tetrahydrofuran (12 mL) following the experimental procedure as described for intermediate 42.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09315463B2 |
| Source dataset | uspto-grants-2016_04 |
| ORD ID | ord-d32ba8ac49a64ebcb2d843b47ea0414c |
| Source note | uspto-grants-2016_04 |