HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chloride → N-[4-({[tert-butyl(dimethyl)silyl]oxy}methyl)-3-methoxyphenyl]acrylamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chloride | HCID 312 | — |
| Reactant | N-[4-({[tert-butyl(dimethyl)silyl]oxy}methyl)-2-chloro-5-methoxyphenyl]-acrylamide | HCID 67145019 | — |
| Reactant | Diethyldiisopropylamine | HCID 129867302 | — |
| Product | N-[4-({[tert-butyl(dimethyl)silyl]oxy}methyl)-3-methoxyphenyl]acrylamide | HCID 67469526 | — |
Reaction Steps
Obtained as a solid (63%) from [4-({[tert-butyl(dimethyl)silyl]oxy}methyl)-3-methoxyphenyl]amine (intermediate 99; 5 g, 18.7 mmol), acryloil chloride (1.98 mL, 24.28 mmol) and diethyldiisopropylamine (4.9 mL, 28.06 mmol) following the experimental procedure as described in intermediate 40. The crude obtained was purified by column chromatography with silica gel, eluting with methylene chloride.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09315463B2 |
| Source dataset | uspto-grants-2016_04 |
| ORD ID | ord-cdbbf9f8ce6f4afcaeb5d1ad7d278e1e |
| Source note | uspto-grants-2016_04 |