HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium → N-[4-({[tert-butyl(dimethyl)-silyl]oxy}methyl)-2-fluorophenyl]acrylamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium | HCID 5360545 | — |
| Reactant | N-[4-({[tert-butyl(dimethyl)-silyl]oxy}methyl)-2-fluorophenyl]acrylamide | HCID 67469489 | — |
| Reactant | HCID 178484861 | HCID 178484861 | — |
| Product | N-[4-({[tert-butyl(dimethyl)-silyl]oxy}methyl)-2-fluorophenyl]acrylamide | HCID 67469489 | — |
| Product | HCID 178483941 | HCID 178483941 | — |
| Product | HCID 178484861 | HCID 178484861 | — |
Reaction Steps
The title compound was obtained (44%) from N-[4-({[tert-butyl(dimethyl)-silyl]oxy}methyl)-2-fluorophenyl]acrylamide (intermediate 117; 0.5 g, 1.62 mmol), trans-4-(methylamino)cyclohexyl hydroxy(di-2-thienyl)acetate (intermediate 5, 0.51 g, 1.46 mmol) and sodium triacetoxyhydroborate (1.1 g, 5.24 mmol) following the experimental procedure as described in intermediate 30, followed by a purification by preparative reversed-phase HPLC (System 2).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09315463B2 |
| Source dataset | uspto-grants-2016_04 |
| ORD ID | ord-08294f6ab4a54211bf7c6d94c1771d7a |
| Source note | uspto-grants-2016_04 |