HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Chlorophenylboronic acid → (1-(5-(2-Chlorophenyl)pyrimidin-2-yl)-3-(methylthio)-1H-indol-6-yl)(morpholino)methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Chlorophenylboronic acid | HCID 2734322 | — |
| Reactant | (1-(5-Bromopyrimidin-2-yl)-3-(methylthio)-1H-indol-6-yl)(morpholino)methanone | HCID 118666053 | — |
| Product | (1-(5-(2-Chlorophenyl)pyrimidin-2-yl)-3-(methylthio)-1H-indol-6-yl)(morpholino)methanone | HCID 118666113 | — |
Reaction Steps
Synthesized according to general procedure 1 from (1-(5-bromopyrimidin-2-yl)-3-(methylthio)-1H-indol-6-yl)(morpholino)methanone (1.0 g, 2.30 mmol, 1.0 eq) and (2-chlorophenyl)boronic acid (0.429 g, 2.77 mmol, 1.2 eq). Yield: 0.7 g (65% of theory).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09315490B2 |
| Source dataset | uspto-grants-2016_04 |
| ORD ID | ord-34dcaef13bea4fa9afc9a41bbb370f2e |
| Source note | uspto-grants-2016_04 |