HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Chloro-5-phenylpyrimidine → tert-Butyl 4-(3-(methylthio)-1-(5-phenylpyrimidin-2-yl)-1H-indole-6-carbonyl)piperazine-1-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Chloro-5-phenylpyrimidine | HCID 605320 | — |
| Reactant | (1-(5-Bromopyrimidin-2-yl)-3-(methylthio)-1H-indol-6-yl)(morpholino)methanone | HCID 118666053 | — |
| Reactant | tert-Butyl 4-(3-(methylthio)-1H-indole-6-carbonyl)piperazine-1-carboxylate | HCID 131735390 | — |
| Product | tert-Butyl 4-(3-(methylthio)-1-(5-phenylpyrimidin-2-yl)-1H-indole-6-carbonyl)piperazine-1-carboxylate | HCID 131735389 | — |
Reaction Steps
Prepared from the product of 12b) (1.2 g, 3.2 mmol, 1.0 eq) and 2-chloro-5-phenylpyrimidine (0.604 g, 3.2 mmol, 1.0 eq) following the instructions of 1c). Yield: 700 mg.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09315490B2 |
| Source dataset | uspto-grants-2016_04 |
| ORD ID | ord-7387f739605148188cacd0ab8474dacd |
| Source note | uspto-grants-2016_04 |