HuagongsheHuagongshe Chemistry Print Report · For research reference only
(3-(Methylsulfinyl)-1-(5-phenylpyrimidin-2-yl)-1H-indol-6-yl)(piperazin-1-yl)methanone → (1-(5-(2-Fluorophenyl)pyrimidin-2-yl)-3-(methylsulfinyl)-1H-indol-6-yl)(piperazin-1-yl)methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (3-(Methylsulfinyl)-1-(5-phenylpyrimidin-2-yl)-1H-indol-6-yl)(piperazin-1-yl)methanone | HCID 118666184 | — |
| Reactant | tert-Butyl 4-(1-(5-(2-fluorophenyl)pyrimidin-2-yl)-3-(methylsulfinyl)-1H-indole-6-carbonyl)piperazine-1-carboxylate | HCID 131735392 | — |
| Product | (1-(5-(2-Fluorophenyl)pyrimidin-2-yl)-3-(methylsulfinyl)-1H-indol-6-yl)(piperazin-1-yl)methanone | HCID 118671941 | — |
Reaction Steps
Prepared from 13c) (170 mg, 0.30 mmol, 1.0 eq) in analogy to the procedure of 12e). White solid. Yield: 130 mg (71% of theory). Melting range: 199-203° C. HPLC (method 3): Rt=4.04 min. Mass spectroscopy: m/z: [M+H]+=464.1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09315490B2 |
| Source dataset | uspto-grants-2016_04 |
| ORD ID | ord-93311710b5a4444d90809ecc2d21ec1a |
| Source note | uspto-grants-2016_04 |