反应详情

Sodium borohydride (220 mg, 5.81 mmol, 3.0 eq) was added to a stirred solution of product 27a) (500 mg, 1.94 mmol, 1.0 eq) in methanol (10 mL) at room temperature and stirring was continued for 2 h. The methanol was removed under vacuum, water (50 mL) was added, and the mixture was extracted with ethyl acetate (2×30 mL). The combined organic layers were washed with brine (50 mL), dried over sodium sulfate, and evaporated. White solid. Yield: 400 mg (80% of theory).

1. customThe methanol was removed under vacuum, water (50 mL)
2. additionwas added
3. extractionthe mixture was extracted with ethyl acetate (2×30 mL)
4. washThe combined organic layers were washed with brine (50 mL)
5. dry with materialdried over sodium sulfate
6. customevaporated